Last updated: January 18th, 2020
Introduction :
Protein dephosphorylation is an important post-translation modification (PTM), Since 1983, many kinds of phosphatases have been discovered. Despite the long history of its discovery. Compared with huge achievement on protein kinases and phosphorylation fields, the studies on protein-specific dephosphorylation in the bio-computational field are so lack. The experimental identification of protein dephosphorylation sites is labor-extensive and expensive. Thus, a computational tool of prediction is needed.
We apologized that the computational studies without any web links of databases or tools will not be included in this compendium, since it's not easy for experimentalists to use studies directly. We are grateful for users feedback. Please inform Yu Xue to add, remove or update one or multiple web links below.
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Protein Dephosphorylation and Phosphatase Database :
1. PhosphoregDB (Service stopped,): the tissue and sub-cellular distribution of mammalian protein kinases and phosphatases (Forrest AR et al, 2006).
2. HUPHO: the human phosphatase portal (Liberti S et al., 2012).
3. DEPOD:The human DEPhOsphorylation database DEPOD (Duan G et al., 2015).
4. PTP-central: a comprehensive resource of protein tyrosine phosphatases in eukaryotic genomes. (Hatzihristidis T et al., 2013).
5. PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae (Stark C et al., 2010,Sadowski I et al., 2013).